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In a 2004 interview, Tobias explained his approach as "A and B and C. . . Abstinence works. 'Be faithful' works. Condoms work. They all have a role. But it's not a multiple choice, where there is only one answer."
As a top official overseeing global AIDS funding to other countries, Tobias was responsible for enforcing a U.S. policy, enacted during the Bush administration, that requires recipients to swear they oppose prostitution and sex trafficking. USAID adopted a similar policy in 2004.
Tobias submitted his resignation Friday, one day after confirming to ABC News that he had been a customer of a Washington, D.C. escort service whose owner has been charged by federal prosecutors with running a prostitution operation.
Tobias, 65, director of U.S. Foreign Assistance and administrator of the U.S. Agency for International Development (USAID), had previously served as the ambassador for the President's Emergency Fund for AIDS Relief.
A State Department press release late Friday afternoon said only he was leaving for "personal reasons."
On Thursday, Tobias told ABC News he had several times called the "Pamela Martin and Associates" escort service "to have gals come over to the condo to give me a massage."